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Prolonged recycling of internalized neurotrophins in the nerve terminal

Weible, Michael; Bartlett, Selena; Reynolds, Anna; Hendry, Ian

Description

Background: Neurons require contact with their target tissue in order to survive and make correct connections. The retrograde axonal transport of neurotrophins occurs after receptor-mediated endocytosis into vesicles at the nerve terminal. However, the mechanism by which the neurotrophin signal is propagated from axon terminal to cell body remains unclear. Methods: Retrograde axonal transport was examined using the transport of I125-labeled neurotrophins from the eye to sympathetic and sensory...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/58198
Source: Cytometry
DOI: 10.1002/1097-0320(20010301)43:3<182::AID-CYTO1047>3.0.CO;2-J

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