Prolonged recycling of internalized neurotrophins in the nerve terminal
Background: Neurons require contact with their target tissue in order to survive and make correct connections. The retrograde axonal transport of neurotrophins occurs after receptor-mediated endocytosis into vesicles at the nerve terminal. However, the mechanism by which the neurotrophin signal is propagated from axon terminal to cell body remains unclear. Methods: Retrograde axonal transport was examined using the transport of I125-labeled neurotrophins from the eye to sympathetic and sensory...[Show more]
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