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Estimating the dielectric constant of the channel protein and pore

Ng, Jin; Vora, Taira; Krishnamurthy, Vikram; Chung, Shin-Ho

Description

When modelling biological ion channels using Brownian dynamics (BD) or Poisson-Nernst-Planck theory, the force encountered by permeant ions is calculated by solving Poisson's equation. Two free parameters needed to solve this equation are the dielectric constant of water in the pore and the dielectric constant of the protein forming the channel. Although these values can in theory be deduced by various methods, they do not give a reliable answer when applied to channel-like geometries that...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/58191
Source: European Biophysics Journal
DOI: 10.1007/s00249-007-0218-3

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