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Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis

Stigers, Dannon; Watts, Zachary; Hennessy, James E; Kim, Hye-Kyung; Martini, Romeo; Taylor, Matthew C; Ozawa, Kiyoshi; Keillor, Jeffrey W; Dixon, Nicholas Edward; Easton, Christopher

Description

3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to ∼90%, and substituted protein is catalytically active. By

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/58178
Source: Chemical Communications
DOI: 10.1039/C0CC02879G

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