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Generation of pseudocontact shifts in protein NMR spectra with a genetically encoded cobalt(II)-binding amino acid

Nguyen, Thi Kelly; Ozawa, Kiyoshi; Stanton-Cook, Mitchell; Barrow, Russell; Otting, Gottfried; Huber, Thomas


Playing tag: Incorporation of the genetically encoded amino acid bipyridylalanine into a protein creates a site-specific binding site for CoII. Pronounced pseudocontact shifts generated by the CoII ion in the NMR spectra delivers powerful long-range structure information for the facile analysis of proteins as well as protein-protein and protein-ligand complexes (see picture for a representation of the psuedocontact shift in the protein).

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Angewandte Chemie International Edition
DOI: 10.1002/anie.201005672


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