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Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors

Quek, Gracia X J; Lin, Diana S-H; Halliday, Jill; Absalom, Nathan; Ambrus, Joseph; Thompson, Andrew J; Lochner, Martin; Lummis, Sarah; McLeod, Malcolm; Chebib, Mary

Description

Neuronal nicotinic acetylcholine receptors (nAChR) are ligand gated ion channels that mediate fast synaptic transmission. Methyllycaconitine (MLA) is a selective and potent antagonist of the 7 nAChR, and its anthranilate ester side-chain is important for

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/57985
Source: A C S Chemical Neuroscience
DOI: 10.1021/cn100073x

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