Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors
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Quek, Gracia X J; Lin, Diana S-H; Halliday, Jill; Absalom, Nathan; Ambrus, Joseph; Thompson, Andrew J; Lochner, Martin; Lummis, Sarah; McLeod, Malcolm; Chebib, Mary
Description
Neuronal nicotinic acetylcholine receptors (nAChR) are ligand gated ion channels that mediate fast synaptic transmission. Methyllycaconitine (MLA) is a selective and potent antagonist of the 7 nAChR, and its anthranilate ester side-chain is important for
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/57985 |
Source: | A C S Chemical Neuroscience |
DOI: | 10.1021/cn100073x |
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01_Quek_Identifying_the_binding_site_2010.pdf | 4.17 MB | Adobe PDF | Request a copy |
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