Inhibition of calcium channels by opioid- and adenosine-receptor agonists in neurons of the nucleus accumbens
Description
1. The pharmacological effects of opioid- and adenosine-receptor agonists on neural signalling were investigated by measuring drug actions on barium current flowing through calcium channels in acutely-dissociated neurons of the rat nucleus accumbens (NAc). 2. Under whole-cell voltage clamp, opioids acted via μ, but not δ or κ, receptors to partially inhibit barium current. Mean inhibition was 35±2% (± s.e.mean, n= 33) for methionine-enkephalin and 37 ± 1% (n = 65) for the selective μ receptor...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/57959 |
Source: | British Journal of Pharmacology |
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File | Description | Size | Format | Image |
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01_Chieng_Inhibition_of_calcium_channels_2001.pdf | 202.78 kB | Adobe PDF | Request a copy |
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