Inhibition of calcium channels by opioid- and adenosine-receptor agonists in neurons of the nucleus accumbens
1. The pharmacological effects of opioid- and adenosine-receptor agonists on neural signalling were investigated by measuring drug actions on barium current flowing through calcium channels in acutely-dissociated neurons of the rat nucleus accumbens (NAc). 2. Under whole-cell voltage clamp, opioids acted via μ, but not δ or κ, receptors to partially inhibit barium current. Mean inhibition was 35±2% (± s.e.mean, n= 33) for methionine-enkephalin and 37 ± 1% (n = 65) for the selective μ receptor...[Show more]
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|Source:||British Journal of Pharmacology|
|01_Chieng_Inhibition_of_calcium_channels_2001.pdf||202.78 kB||Adobe PDF||Request a copy|
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