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Antibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage

Sidana, Jasmeen; Rohilla, Rajesh K; Roy, Nilanjan; Barrow, Russell; Foley, William; Singh, Inder Pal

Description

Loxophlebal A, a new antibacterial formylated phloroglucinol was isolated from the mother liquor obtained after separation of sideroxylonals from the chloroform-methanol extract of leaves of Eucalyptus loxophleba ssp lissophloia. The structure of loxophlebal A was determined to be 3-desformyl sideroxylonal A by spectroscopic methods including 1D- and 2D-NMR. The stereochemistry of loxophlebal A was determined by chemical correlation with sideroxylonal A. This article also reports an efficient,...[Show more]

dc.contributor.authorSidana, Jasmeen
dc.contributor.authorRohilla, Rajesh K
dc.contributor.authorRoy, Nilanjan
dc.contributor.authorBarrow, Russell
dc.contributor.authorFoley, William
dc.contributor.authorSingh, Inder Pal
dc.date.accessioned2015-12-10T22:41:06Z
dc.identifier.issn0367-326X
dc.identifier.urihttp://hdl.handle.net/1885/57739
dc.description.abstractLoxophlebal A, a new antibacterial formylated phloroglucinol was isolated from the mother liquor obtained after separation of sideroxylonals from the chloroform-methanol extract of leaves of Eucalyptus loxophleba ssp lissophloia. The structure of loxophlebal A was determined to be 3-desformyl sideroxylonal A by spectroscopic methods including 1D- and 2D-NMR. The stereochemistry of loxophlebal A was determined by chemical correlation with sideroxylonal A. This article also reports an efficient, simple and economic method for large scale isolation of sideroxylonals in a purity of > 90% from the leaves of Eucalyptus loxophleba ssp lissophloia.
dc.publisherElsevier
dc.sourceFitoterapia
dc.subjectKeywords: antiinfective agent; Eucalyptus extract; loxophlebal a; phloroglucinol derivative; sideroxylonal; unclassified drug; antibacterial activity; article; drug isolation; drug structure; Escherichia coli; Eucalyptus; foliage; high performance liquid chromatogr Antibacterial; Eucalyptus loxophleba; Large scale isolation; Loxophlebal A; Sideroxylonals
dc.titleAntibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume81
dc.date.issued2010
local.identifier.absfor060705 - Plant Physiology
local.identifier.absfor030502 - Natural Products Chemistry
local.identifier.ariespublicationu4005981xPUB413
local.type.statusPublished Version
local.contributor.affiliationSidana, Jasmeen, National Institute of Pharmaceutical Education and Research (NIPER)
local.contributor.affiliationRohilla, Rajesh K, National Institute of Pharmaceutical Education and Research (NIPER)
local.contributor.affiliationRoy, Nilanjan, National Institute of Pharmaceutical Education and Research (NIPER)
local.contributor.affiliationBarrow, Russell, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationFoley, William, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSingh, Inder Pal, National Institute of Pharmaceutical Education and Research (NIPER)
local.description.embargo2037-12-31
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage878
local.bibliographicCitation.lastpage883
local.identifier.doi10.1016/j.fitote.2010.05.016
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T10:23:40Z
local.identifier.scopusID2-s2.0-77956701721
local.identifier.thomsonID000282864800036
CollectionsANU Research Publications

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