Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

Approaches to the Synthesis of the Galbulimima Alkaloid Himandrine

O'Connor, Patrick; Del Signore, Giuseppe; McLachlan, Matthew; Willis, Anthony; Mander, Lewis


The hexacyclic skeleton of himandrine (2), which is present in 15 of the more complex alkaloids obtained from the bark of the tropical rain forest tree Galbulimima belgraveana has been prepared by means of a 19-step synthesis beginning with the known [3.2.1]-benzobicyclooctene intermediate 9. An alternative approach is also described, thus far culminating in 34. Key transformations include DielsAlder cycloadditions, ring contractions, a Curtius rearrangement, a Birch reduction, an...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH10252


File Description SizeFormat Image
01_O'Connor_Approaches_to_the_Synthesis_of_2010.pdf715.03 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator