A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine
A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.
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|Source:||Australian Journal of Chemistry|
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