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A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine

Banwell, Martin; Ma, Xinghua; Karunaratne, Ochitha; Willis, Anthony

Description

A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/57635
Source: Australian Journal of Chemistry
DOI: 10.1071/CH10201

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