Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

Relationship between mitochondrial DNA damage and photoreceptor death in developing and adult retina, assessed in normal and degenerative rat strains

Bravo-Nuevo, A; Williams, Neal; Valter (Valter-Kocsi), Krisztina; Stone, Jonathan


In this study, we used Real-Time PCR to study the correlation of mtDNA deletions and photoreceptor death by apoptosis in one normal (SD) and two different degenerative (RCS and P23H) rat strains. Our results show that, in the SD and RCS strains, mtDNA deletion frequency increased and fell during neonatal life, correlating with rates of photoreceptor death during the critical period of photoreceptor development, and into adulthood. Results suggest that mitochondrial damage occurs in close...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Mitochondrion
DOI: 10.1016/j.mito.2007.05.003


File Description SizeFormat Image
01_Bravo-Nuevo_Relationship_between_2007.pdf465.52 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator