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The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila

Bowman, Sarah K; Rolland, Vivien; Betschinger, Joerg; Kinsey, Kaolin A.; Emery, Gregory; Knoblich, Juergen A.


In both vertebrates and insects, neurons typically arise from neural stem cells or terminally dividing intermediate progenitors. Here, we describe another mode of neurogenesis where neural stem cells generate secondary precursors that undergo multiple rounds of self-renewing transit-amplifying divisions. We identify the Posterior Asense-Negative (PAN) neuroblasts, which do not express the transcription factors Asense or Prospero. PAN neuroblasts rely on the segregating determinants Numb and...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Developmental Cell
DOI: 10.1016/j.devcel.2008.03.004


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