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The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila

Bowman, Sarah K; Rolland, Vivien; Betschinger, Joerg; Kinsey, Kaolin A.; Emery, Gregory; Knoblich, Juergen A.

Description

In both vertebrates and insects, neurons typically arise from neural stem cells or terminally dividing intermediate progenitors. Here, we describe another mode of neurogenesis where neural stem cells generate secondary precursors that undergo multiple rounds of self-renewing transit-amplifying divisions. We identify the Posterior Asense-Negative (PAN) neuroblasts, which do not express the transcription factors Asense or Prospero. PAN neuroblasts rely on the segregating determinants Numb and...[Show more]

dc.contributor.authorBowman, Sarah K
dc.contributor.authorRolland, Vivien
dc.contributor.authorBetschinger, Joerg
dc.contributor.authorKinsey, Kaolin A.
dc.contributor.authorEmery, Gregory
dc.contributor.authorKnoblich, Juergen A.
dc.date.accessioned2015-12-10T22:40:21Z
dc.identifier.issn1534-5807
dc.identifier.urihttp://hdl.handle.net/1885/57433
dc.description.abstractIn both vertebrates and insects, neurons typically arise from neural stem cells or terminally dividing intermediate progenitors. Here, we describe another mode of neurogenesis where neural stem cells generate secondary precursors that undergo multiple rounds of self-renewing transit-amplifying divisions. We identify the Posterior Asense-Negative (PAN) neuroblasts, which do not express the transcription factors Asense or Prospero. PAN neuroblasts rely on the segregating determinants Numb and Brat to generate smaller, secondary neuroblasts that in turn give rise to ganglion mother cells (GMCs) and neurons throughout larval development. In brat or numb mutants, misspecified secondary neuroblasts are unable to produce differentiated progeny and initiate tumor-like overgrowth. In prospero mutants, however, tumors arise from GMCs while secondary neuroblasts are correctly specified. Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages.
dc.publisherCell Press
dc.sourceDevelopmental Cell
dc.subjectKeywords: mutant protein; protein Brat; protein Numb; transcription factor; transcription factor Asense; transcription factor Prospero; tumor suppressor protein; unclassified drug; animal cell; animal tissue; article; cell division; cell lineage; cell type; control CELLCYCLE; DEVBIO; STEMCELL
dc.titleThe Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume14
dc.date.issued2008
local.identifier.absfor060805 - Animal Neurobiology
local.identifier.ariespublicationu4956746xPUB400
local.type.statusPublished Version
local.contributor.affiliationBowman, Sarah K , Institute of Molecular Biotechnology of the Austrian Academy of Sciences
local.contributor.affiliationRolland, Vivien, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBetschinger, Joerg, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
local.contributor.affiliationKinsey, Kaolin A., Research Institute of Molecular Pathology
local.contributor.affiliationEmery, Gregory, Institute of Molecular Biotechnology of the Austrian Academy of Sciences
local.contributor.affiliationKnoblich, Juergen A., Institute of Molecular Biotechnology of the Austrian Academy of Sciences
local.description.embargo2037-12-31
local.bibliographicCitation.startpage535
local.bibliographicCitation.lastpage546
local.identifier.doi10.1016/j.devcel.2008.03.004
local.identifier.absseo920102 - Cancer and Related Disorders
dc.date.updated2015-12-09T10:58:12Z
local.identifier.scopusID2-s2.0-41649093071
CollectionsANU Research Publications

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