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Class 1 genes have split from the MHC in the tammar wallaby

Deakin, Janine; Siddle, Hannah V; Cross, Joe; Belov, Katherine; Graves, Jennifer

Description

Genes within the Major Histocompatibility Complex (MHC) are critical to the immune response and immunoregulation. Comparative studies have revealed that the MHC has undergone many changes throughout evolution yet in tetrapods the three different classes of MHC genes have maintained linkage, suggesting that there may be some functional advantage obtained by maintaining this clustering of MHC genes. Here we present data showing that class II and III genes, the antigen processing gene TAP2, and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/57140
Source: Cytogenetic and Genome Research
DOI: 10.1159/000098188

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