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Mapping playtpus SOX genes; autosomal location of SOX9 excludes it from sex determining role

Wallis, Mary; Delbridge, Margaret; Pask, Andrew J; Alsop, Amber; Grutzner, Frank; O'Brien, Patricia C M; Rens, Willem; Ferguson-Smith, Malcolm A; Graves, Jennifer


In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Cytogenetic and Genome Research
DOI: 10.1159/000098192


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