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Recruitment of old genes to new functions: evidences obtained by comparing the orthologues of human XLMR genes in mouse and chicken

Kohn, Matthias; Kehrer-Sawatzki, Hildegard; Steinbach, Peter; Graves, Jennifer; Hameister, Horst


Gene mapping data indicate that the human X chromosome is enriched in genes that affect both, higher cognitive efficiency and reproductive success. This raises the question whether these functions are ancient, or whether conserved X-linked genes were recruited to new functions. We have studied three X-linked mental retardation (XLMR) genes by RNA in situ hybridization in mouse and in chicken, in which these genes are autosomal: Rho guanine nucleotide exchange factor 6 (ARHGEF6), oligophrenin...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Cytogenetic and Genome Research
DOI: 10.1159/000098183


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