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Search for the sex-determining switch in monotremes: Mapping WT1, SF1, LHX1, FGF9, WNT4, RSPO1 and GATA4 in platypus

Graphodatskaya, Daria; Rens, Willem; Wallis, Mary C; Trifonov, Vladimir A; O'Brien, Patricia C M; Clarke, Oliver; Graves, Jennifer; Ferguson-Smith, Malcolm A

Description

The duck-billed platypus has five pairs of sex chromosomes, but there is no information about the primary sex-determining switch in this species. As there is no apparent SRY orthologue in platypus, another gene must acquire the function of a key regulator of the gonadal male or female fate. SOX9 was ruled out from being this key regulator as it maps to an autosome in platypus. To check whether other genes in mammalian gonadogenesis could be the primary switch in monotremes, we have mapped a...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/56802
Source: Chromosome Research
DOI: 10.1007/s10577-007-1161-y

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