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Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites

Bellanca, Sebastiano; Summers, Robert; Meyrath, Max; Dave, Anurag; Nash, Megan; Dittmer, Martin; Sanchez, Cecilia P.; Stein, Wilfred D.; Martin, Rowena; Lanzer, Michael


Mutations in the "chloroquine resistance transporter" (PfCRT) are a major determinant of drug resistance in the malaria parasite Plasmodium falciparum. We have previously shown that mutant PfCRT transports the antimalarial drug chloroquine away from its target, whereas the wild-type form of PfCRT does not. However, little is understood about the transport of other drugs via PfCRT or the mechanism by which PfCRT recognizes different substrates. Here we show that mutant PfCRT also transports...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M114.614206


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