Wallis, Mary; Waters, Paul; Delbridge, Margaret; Kirby, Patrick J; Pask, Andrew J; Grutzner, Frank; Rens, Willem; Ferguson-Smith, Malcolm A; Graves, Jennifer
In eutherian ('placental') mammals, sex is determined by the presence or absence of the Y chromosome-borne gene SRY, which triggers testis determination. Marsupials also have a Y-borne SRY gene, implying that this mechanism is ancestral to therians, the SRY gene having diverged from its X-borne homologue SOX3 at least 180 million years ago. The rare exceptions have clearly lost and replaced the SRY mechanism recently. Other vertebrate classes have a variety of sex-determining mechanisms, but...[Show more]
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