Statistical Tests between Competing Hypotheses of Hox Cluster Evolution
The Hox genes encode transcription factors that play vital roles in the anterior-posterior patterning of all bilaterian phyla studied to date. Additionally, the gain of Hox genes by duplication has been widely implicated as a driving force in the evolution of animal body plans. Because of this, reconstructing the evolution of the Hox cluster has been the focus of intense research interest. It has been commonly assumed that an ancestral four-gene ProtoHox cluster was duplicated early in animal...[Show more]
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