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Design of a novel disposable piezoelectric co-polymer diaphragm based biosensor unit

XIAO, Yinghong; Liu, Yun; Borg, Gerard; Li, Chang Ming

Description

Piezoelectric biosensors represent an economic alternative suitable for the detection of a variety of biomolecules. However, the difficulty of forming diverse structures and shapes using conventional piezoelectric ceramic and quartz crystals has so far limited their potential applications. Piezoelectric polymers and their co-polymers are considered as the favourable choice in the fabrication of different types of sensors due to their low cost, light weight and ease in forming delicate shapes....[Show more]

dc.contributor.authorXIAO, Yinghong
dc.contributor.authorLiu, Yun
dc.contributor.authorBorg, Gerard
dc.contributor.authorLi, Chang Ming
dc.date.accessioned2015-12-10T22:34:52Z
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/1885/56050
dc.description.abstractPiezoelectric biosensors represent an economic alternative suitable for the detection of a variety of biomolecules. However, the difficulty of forming diverse structures and shapes using conventional piezoelectric ceramic and quartz crystals has so far limited their potential applications. Piezoelectric polymers and their co-polymers are considered as the favourable choice in the fabrication of different types of sensors due to their low cost, light weight and ease in forming delicate shapes. This paper demonstrates a disposable and simple piezoelectric diaphragm sensing platform consisting of a flexible co-polymer thin film and plastic sample holder. To test this platform, protein A was immobilized to form a bridge between goat immunoglobulin G (IgG) probe molecules and the gold electrode on the surface of poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] film. The designed polyetheretherketone sample holders were applied to fix the piezoelectric co-polymer films. The apparatus was successfully used as an immunosensor and had the added advantage that the co-polymer thin film could be replaced. Optimum concentration of goat IgG probe molecules for fabricating the immunosensors was determined to be 3 mg/mL. The P(VDF-TrFE)-based immunosensor of this type shows a good reproducibility and a broad dynamic detection range.
dc.publisherElsevier
dc.sourceMaterials Science and Engineering: C
dc.subjectKeywords: Dynamic detection range; Gold electrodes; Immunoglobulin G; Light weight; Low costs; Optimum concentration; P(VDF-TrFE); Piezoelectric; Piezoelectric biosensors; Piezoelectric diaphragms; Piezoelectric polymers; Plastic sample; Poly(vinylidene fluoride-tr Co-polymer; Immunosensor unit; P(VDF-TrFE); Piezoelectric; Thin film
dc.titleDesign of a novel disposable piezoelectric co-polymer diaphragm based biosensor unit
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume31
dc.date.issued2011
local.identifier.absfor030606 - Structural Chemistry and Spectroscopy
local.identifier.absfor020404 - Electronic and Magnetic Properties of Condensed Matter; Superconductivity
local.identifier.absfor020401 - Condensed Matter Characterisation Technique Development
local.identifier.ariespublicationu4326120xPUB349
local.type.statusPublished Version
local.contributor.affiliationXIAO, Yinghong, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLiu, Yun, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBorg, Gerard, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLi, Chang Ming , Nanyang Technological University
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage95
local.bibliographicCitation.lastpage98
local.identifier.doi10.1016/j.msec.2010.08.006
local.identifier.absseo899899 - Environmentally Sustainable Information and Communication Services not elsewhere classified
dc.date.updated2016-02-24T10:56:10Z
local.identifier.scopusID2-s2.0-78650714893
local.identifier.thomsonID000286707900005
CollectionsANU Research Publications

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