Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice
Huynh, Tony; Uaesoontrachoon, Kitipong; Quinn, James; Tatem, Kathleen S; Heier, Christopher; Van Der Meulen, Jack H; Yu, Qing; Harris, Mark; Nolan, Christopher; Haegeman, Guy; Grounds, Miranda D; Nagaraju, Kanneboyina
The over-expression of NF-κB signalling in both muscle and immune cells contribute to the pathology in dystrophic muscle. The anti-inflammatory properties of glucocorticoids, mediated predominantly through monomeric glucocorticoid receptor inhibition of
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|Source:||Journal of Pathology|
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