Gregory, Stephen L; Shandala, Tetyana; O'Keefe, Louise V; Jones, Lynn; Murray, Michael; Saint, Robert
To identify genes that modulate Rho signalling during cytokinesis we tested the effect of overexpressing a set of 2190 genes on an eye phenotype caused by defective Rho activation. The resulting 112 modifier loci fell into three main classes: cell cycle genes, signalling effectors and metabolic enzymes. We developed a further series of genetic tests to refine the interactors into those most likely to modify Rho signalling during cytokinesis. In addition to a number of genes previously...[Show more]
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