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Hippocampal shape analysis for Alzheimer's disease using an efficient hypothesis test and regularised discriminative deformation

Zhou, Luping; Lieby, Paulette; Barnes, Nick; Meslin, Chantal; Walker, Janine; Cherbuin, Nicolas; Hartley, Richard

Description

In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are preferred to traditional hypothesis tests which impose assumptions on the distribution of the samples. In this article, an efficient algorithm is adopted to rapidly perform the exact...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/55975
Source: Hippocampus
DOI: 10.1002/hipo.20639

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