Skip navigation
Skip navigation

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D 2 synthase

Weber, Jane E; Oakley, Aaron; Christ, Angelika N; Clark, Alan G; Hayes, John D; Hall, Rhonda; Hume, David A; Board, Philip; Smythe, Mark L; Flanagan, Jack U


Prostaglandin D2 synthesised by the hematopoietic prostaglandin D2 synthase has a pro-inflammatory effect in allergic asthma, regulating many hallmark characteristics of the disease. Here we describe identification of hematopoietic prostaglandin D2 synthase inhibitors including cibacron blue, bromosulfophthalein and ethacrynic acid. Expansion around the drug-like ethacrynic acid identified a novel inhibitor, nocodazole, and a fragment representing its aromatic core. Nocodazole binding was...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: European Journal of Medicinal Chemistry
DOI: 10.1016/j.ejmech.2009.10.025


File Description SizeFormat Image
01_Weber_Identification_and_2010.pdf861.89 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator