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Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation

Jones, Whitney M; Chao, Anna T.; Zavortink, Michael; Saint, Robert; Bejsovec, Amy

Description

Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos and maintain stem-cell populations in many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading to cancer. We have discovered that two Drosophila proteins that are crucial for cytokinesis have a second, largely independent, role in restricting activity of the Wnt pathway. The fly homolog of RacGAP1, Tumbleweed (Tum)/RacGAP50C, and its binding partner, the kinesin-like...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/55903
Source: Journal of Cell Science
DOI: 10.1242/jcs.067868

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