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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Yu, Di; Tan, Andy Hee-Meng; Hu, Xin; Athanasopoulos, Vicki; Simpson, Nick; Silva, Diego; Hutloff, Andreas; Giles, Keith M; Leedman, Peter J; Lam, Kong Peng; Goodnow, Christopher; Garcia De Vinuesa, Maria Carola


Immune responses are normally targeted against microbial pathogens and not self-antigens by mechanisms that are only partly understood. Here we define a newly discovered pathway that prevents autoimmunity by limiting the levels on T lymphocytes of a co-stimulatory receptor, the inducible T-cell co-stimulator (ICOS). In sanroque mice homozygous for an M199R mutation in the ROQ domain of Roquin (also known as Rc3h1), increased Icos expression on T cells causes the accumulation of lymphocytes that...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Nature
DOI: 10.1038/nature06253


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