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Dependence of the Properties of Cobalt(III) Cage Complex as a Function of the Derivatization of Amine Substituents

Sargeson, Alan; Lay, Peter

Description

Control of redox properties of cobalt macrobicyclic hexaamine (cage) complexes by substituent modification is important for their use as electron-transfer agents, and the resultant derivatives can also change the lipophilicity of the complexes for a variety of biological and other applications. Such derivatization is also important for incorporating cage complexes into a range of redoxactive conjugates. Here, the derivatization of the amine groups in the 1 and 8 positions of [Co(sar)]3+ (sar =...[Show more]

dc.contributor.authorSargeson, Alan
dc.contributor.authorLay, Peter
dc.date.accessioned2015-12-10T22:32:26Z
dc.identifier.issn0004-9425
dc.identifier.urihttp://hdl.handle.net/1885/55760
dc.description.abstractControl of redox properties of cobalt macrobicyclic hexaamine (cage) complexes by substituent modification is important for their use as electron-transfer agents, and the resultant derivatives can also change the lipophilicity of the complexes for a variety of biological and other applications. Such derivatization is also important for incorporating cage complexes into a range of redoxactive conjugates. Here, the derivatization of the amine groups in the 1 and 8 positions of [Co(sar)]3+ (sar = sarcophagine = 3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane) are reported. The synthesis and properties of methylamide (from the reactions with acetic anhydride), arylimine (from Schiff base reactions), benzylamine, phthalimido, and tosylate derivatives are described. These reactions provide synthons that have the potential to act as precursors for building a range of conjugates containing metal cage complexes, including dimers. The effects of the substituents on the ligand conformations, which affect other chemical and physical properties of the cage complexes, are discussed.
dc.publisherCSIRO Publishing
dc.sourceAustralian Journal of Chemistry
dc.subjectKeywords: Acetic anhydrides; Amine groups; Benzylamines; Cage complexes; Derivatization of; Derivatizations; Electron-transfer; Ligand conformations; Lipophilicity; Metal cage; Other applications; Redox property; Redox-active; Schiff base reaction; Synthons; Amines
dc.titleDependence of the Properties of Cobalt(III) Cage Complex as a Function of the Derivatization of Amine Substituents
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume62
dc.date.issued2009
local.identifier.absfor030201 - Bioinorganic Chemistry
local.identifier.ariespublicationu4005981xPUB339
local.type.statusPublished Version
local.contributor.affiliationSargeson, Alan, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLay, Peter, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue10
local.bibliographicCitation.startpage1280
local.bibliographicCitation.lastpage1290
local.identifier.doi10.1071/CH09368
dc.date.updated2016-02-24T10:23:14Z
local.identifier.scopusID2-s2.0-70350148697
CollectionsANU Research Publications

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