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An investigation into the potential of SarAr for use in 64 Cu radioimmunotherapy

Di Bartolo, Nadine; Smith, Suzanne; Hetherington, Eric; Sargeson, Alan

Description

The B72.3 monoclonal antibody was radiolabelled with 123I, and with 111In and 64Cu, using DTPA and SarAr, respectively. Their biodistribution in tumour-bearing nude mice was used to calculate the dosimetry of their respective therapeutic analogue, using 131I, 90Y, 67Cu, and 64Cu. Two dosimetry models were used: one using the classical approach and a second model that takes into consideration the chemical stability of the radiolabelling methods employed and the biological clearance of each...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/55732
Source: Australian Journal of Chemistry
DOI: 10.1071/CH09369

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