Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss
Chen, Weiqiang; Foo, Suan-Sin; Rulli, Nestor E.; Taylor, Adam; Sheng, Kuo-Ching; Herrero, Lara; Herring, Belinda L.; Lidbury, Brett; Li, Rachel; Walsh, Nicole C.; Sims, Natalie A.; Smith, Paul; Mahalingam, Suresh
Arthritogenic alphaviruses including Ross River virus (RRV), Sindbis virus, and chikungunya virus cause worldwide outbreaks of musculoskeletal disease. The ability of alphaviruses to induce bone pathologies remains poorly defined. Here we show that primary human osteoblasts (hOBs) can be productively infected by RRV. RRV-infected hOBs produced high levels of inflammatory cytokine including IL-6. The RANKL/OPG ratio was disrupted in the synovial fluid of RRV patients, and this was accompanied by...[Show more]
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