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Target-induced natural killer cell loss as a measure of NK cell responses

Warren, Hilary


The interaction of natural killer cells with susceptible target cells triggers NK cell activation, eliciting not only NK cell cytotoxicity and cytokine secretion, but also NK cell death. This study shows that following target cell interaction there is a substantial loss of NK cells, the extent of which correlates with measures of NK cell cytotoxicity assessed by the target cell release of51Cr and by the externalisation of the lysosomal marker LAMP-1 (CD107a) which is assessed on the remaining...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Immunological Methods
DOI: 10.1016/j.jim.2011.06.002


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