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[Ln(DPA) 3 ] 3- is a convenient paramagnetic shift reagent for protein NMR studies

Su, Xun-Cheng; Liang, Haobo; Loscha, Karin; Otting, Gottfried


(Chemical Equation Presented) Paramagnetic lanthanide ions present outstanding tools for structural biology by NMR spectroscopy. Here we show that the 3:1 complexes between dipicolinic acid and lanthanides are paramagnetic reagents which can site-specifically bind to a wide range of proteins without formation of a covalent bond. The observed pseudocontact shifts can be interpreted by a single magnetic susceptibility anisotropy tensor, enabling its use for structure refinements. The resonance...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja9034957


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