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The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells

Li, Rachel; Kirkland, N T; Truong, John; Wang, Jian; Smith, Paul; Birbilis, Nick; Nisbet, David


The postdegradation effect of pure Mg, Mg-1Y, Mg-5Al, and Mg-2Ca alloys on the differentiation, proliferation and gene expression of human mesenchymal stem cells (hMSCs) was investigated. It was revealed that that Mg2+ ions result in an increase in cell proliferation. However, we observed a maximum concentration (approximately 8.0 × 10-4 M) that was favourable to ATP production, above which ATP production began to decrease. In contrast to proliferation, no maximum concentration for osteogenic...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Biomedical Materials Research. Part A
DOI: 10.1002/jbm.a.35111


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