Skip navigation
Skip navigation

Rapid and Enantioselective Assembly of the Lycorine Framework Using Chemoenzymatic Techniques

Jones, Matthew; Schwartz, Brett; Willis, Anthony; Banwell, Martin

Description

The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene. The methodology has been used in developing the first synthesis of compound 2, a derivative of lycorine.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/55316
Source: Organic Letters
DOI: 10.1021/ol901364n

Download

File Description SizeFormat Image
01_Jones_Rapid_and_Enantioselective_2009.pdf424.2 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator