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Rapid and Enantioselective Assembly of the Lycorine Framework Using Chemoenzymatic Techniques

Jones, Matthew; Schwartz, Brett; Willis, Anthony; Banwell, Martin


The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene. The methodology has been used in developing the first synthesis of compound 2, a derivative of lycorine.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Organic Letters
DOI: 10.1021/ol901364n


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