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Multiple actions of {varphi}-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

Smith, Jennifer J.; Vetter, Irina; Lewis, Richard J.; Peigneur, Steve; Tytgat, Jan; Lam, Alex; Gallant, Esther; Beard, Nicole; Alewood, Paul F; Dulhunty, Angela

Description

We recently reported the isolation of a scorpion toxin named U1-liotoxin-Lw1a (U1-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed hairpin (DDH) motif, which is the proposed evolutionary structural precursor of the three-disulfide-c

dc.contributor.authorSmith, Jennifer J.
dc.contributor.authorVetter, Irina
dc.contributor.authorLewis, Richard J.
dc.contributor.authorPeigneur, Steve
dc.contributor.authorTytgat, Jan
dc.contributor.authorLam, Alex
dc.contributor.authorGallant, Esther
dc.contributor.authorBeard, Nicole
dc.contributor.authorAlewood, Paul F
dc.contributor.authorDulhunty, Angela
dc.date.accessioned2015-12-10T22:30:53Z
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/55285
dc.description.abstractWe recently reported the isolation of a scorpion toxin named U1-liotoxin-Lw1a (U1-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed hairpin (DDH) motif, which is the proposed evolutionary structural precursor of the three-disulfide-c
dc.publisherNational Academy of Sciences (USA)
dc.rightsAuthor/s retain copyright
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.subjectKeywords: liotoxin; ryanodine receptor; scorpion disulfide directed hairpin toxin; scorpion inhibitor cystine knot toxin; scorpion venom; toxin; unclassified drug; calcium channel L type; disulfide; tritium; article; binding site; calcium transport; malignant hyper
dc.titleMultiple actions of {varphi}-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume110
dc.date.issued2013
local.identifier.absfor060199 - Biochemistry and Cell Biology not elsewhere classified
local.identifier.ariespublicationu4020362xPUB324
local.type.statusPublished Version
local.contributor.affiliationSmith, Jennifer J., University of Queensland
local.contributor.affiliationVetter, Irina, University of Queensland
local.contributor.affiliationLewis, Richard J., University of Queensland
local.contributor.affiliationPeigneur, Steve, University of Leuven
local.contributor.affiliationTytgat, Jan, University of Leuven
local.contributor.affiliationLam, Alex, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGallant, Esther, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBeard, Nicole, University of Canberra
local.contributor.affiliationAlewood, Paul F, University of Queensland
local.contributor.affiliationDulhunty, Angela, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue22
local.bibliographicCitation.startpage8906
local.bibliographicCitation.lastpage8911
local.identifier.doi10.1073/pnas.1214062110
dc.date.updated2016-02-24T10:27:57Z
local.identifier.scopusID2-s2.0-84878468402
local.identifier.thomsonID000320500000048
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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