Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer
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Chen, Long; Chandra, Arin; Board, Philip; Rangasamy, Danny; Dahlstrom, Jane
Description
Long interspersed nuclear element 1 (L1) belongs to a family of retrotransposons. Expression of the normally repressed L1 retrotransposons has been shown to induce genome instability by creating DNA double-stranded breaks and chromosomal rearrangements through the process of retrotransposition. At present, little is known about the expression of L1-encoded ORF1p and ORF2p which are indispensable for its retrotransposition activity. Given its potentially harmful effects on the genome, we...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/55073 |
Source: | Breast Cancer Research and Treatment |
DOI: | 10.1007/s10549-012-2246-7 |
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01_Chen_Prognostic_value_of_LINE-1_2012.pdf | 757.01 kB | Adobe PDF |
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