Skip navigation
Skip navigation

Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer

Chen, Long; Chandra, Arin; Board, Philip; Rangasamy, Danny; Dahlstrom, Jane


Long interspersed nuclear element 1 (L1) belongs to a family of retrotransposons. Expression of the normally repressed L1 retrotransposons has been shown to induce genome instability by creating DNA double-stranded breaks and chromosomal rearrangements through the process of retrotransposition. At present, little is known about the expression of L1-encoded ORF1p and ORF2p which are indispensable for its retrotransposition activity. Given its potentially harmful effects on the genome, we...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Breast Cancer Research and Treatment
DOI: 10.1007/s10549-012-2246-7


File Description SizeFormat Image
01_Chen_Prognostic_value_of_LINE-1_2012.pdf757.01 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator