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Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer

Chen, Long; Chandra, Arin; Board, Philip; Rangasamy, Danny; Dahlstrom, Jane

Description

Long interspersed nuclear element 1 (L1) belongs to a family of retrotransposons. Expression of the normally repressed L1 retrotransposons has been shown to induce genome instability by creating DNA double-stranded breaks and chromosomal rearrangements through the process of retrotransposition. At present, little is known about the expression of L1-encoded ORF1p and ORF2p which are indispensable for its retrotransposition activity. Given its potentially harmful effects on the genome, we...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/55073
Source: Breast Cancer Research and Treatment
DOI: 10.1007/s10549-012-2246-7

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