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Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors

Zhao, Xin; Jie, Yanling; Rosenberg, Matthew; Wan, Junting; Zeng, Shaogao; Cui, Wei; Xiao, Yiping; Li, Zhiyuan; Tu, Zhengchao; Casarotto, Marco; Hu, Wenhui


The adamantanes are a class of anti-influenza drugs that inhibit the M2 ion channel of the influenza A virus. However recently, the clinical effectiveness of these drugs has been called into question due to the emergence of adamantane-insensitive A/M2 mutants. Although we previously reported (1R,2R,3R,5S)-3-pinanamine 3 as a novel inhibitor of the wild type influenza A virus M2 protein (WT A/M2), limited inhibition was found for adamantane-resistant M2 mutants. In this study, we explored...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Antiviral Research
DOI: 10.1016/j.antiviral.2012.09.001


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