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Biological evaluation of ent -narciclasine, ent -lycoricidine and certain enantiomerically-related congeners

Matveenko, Maria; Banwell, Martin; Joffe, Max; Wan, Soosan; Fantino, Emmanuelle


The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Chemistry & Biodiversity
DOI: 10.1002/cbdv.200800319


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