Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis
Domingo, Maria P; Colmenarejo, Cristina; Martínez-Lostao, Luis; Mullbacher, Arno; Jarne, Carmen; Revillo, Maria J; Delgado, Pilar; Roc, Lourdes; Meis, Jacques F; Rezusta, Antonio; Pardo, Julian; Gálvez, Eva M
The virulence factor gliotoxin (GT) and its inactive derivative, bis(methylthio)gliotoxin (bmGT), are produced by pathogens of the genus . Aspergillus. Here we report the detection of GT and bmGT in serum of humans at risk of invasive aspergillosis (IA) as well as in cultures of fungal isolates derived from patients with proven infection with . A. fumigatus. Although both compounds are readily recoverable from spiked human serum or plasma, only bmGT is retained in whole blood, indicating that...[Show more]
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