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Selective modulation of different GABA(A) receptor isoforms by diazepam and etomidate in hippocampal neurons

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Seymour, Victoria; Curmi, John; Howitt, Susan; Casarotto, Marco; Laver, Derek Rowland; Tierney, Mary (Louise)

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Diazepam modulation of native γ2-containing GABAA (γGABAA) receptors increases channel conductance by facilitating protein interactions involving the γ2-subunit amphipathic (MA) region, which is found in the cytoplasmic loop between transmembrane domai

dc.contributor.authorSeymour, Victoria
dc.contributor.authorCurmi, John
dc.contributor.authorHowitt, Susan
dc.contributor.authorCasarotto, Marco
dc.contributor.authorLaver, Derek Rowland
dc.contributor.authorTierney, Mary (Louise)
dc.date.accessioned2015-12-10T22:29:00Z
dc.identifier.issn1357-2725
dc.identifier.urihttp://hdl.handle.net/1885/54700
dc.description.abstractDiazepam modulation of native γ2-containing GABAA (γGABAA) receptors increases channel conductance by facilitating protein interactions involving the γ2-subunit amphipathic (MA) region, which is found in the cytoplasmic loop between transmembrane domai
dc.publisherPergamon-Elsevier Ltd
dc.sourceThe International Journal of Biochemistry and Cell Biology
dc.subjectKeywords: 4 aminobutyric acid A receptor; diazepam; etomidate; gamma (392 422) MA peptide; peptide; unclassified drug; amino acid sequence; animal cell; article; brain nerve cell; controlled study; drug protein binding; female; hippocampus; ion conductance; male; n Amphipathic region; Diazepam; Etomidate; GABAA receptor; Ion channel; Protein interactions; Single-channel recording
dc.titleSelective modulation of different GABA(A) receptor isoforms by diazepam and etomidate in hippocampal neurons
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume44
dc.date.issued2012
local.identifier.absfor110903 - Central Nervous System
local.identifier.ariespublicationu4020362xPUB308
local.type.statusPublished Version
local.contributor.affiliationSeymour, Victoria, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCurmi, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHowitt, Susan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCasarotto, Marco, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLaver, Derek Rowland, University of Newcastle
local.contributor.affiliationTierney, Mary (Louise), College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage1491
local.bibliographicCitation.lastpage1500
local.identifier.doi10.1016/j.biocel.2012.06.001
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
dc.date.updated2016-02-24T10:27:50Z
local.identifier.scopusID2-s2.0-84862757100
local.identifier.thomsonID000307092400014
CollectionsANU Research Publications

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