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Cognitive ability, intraindividual variability and common genetic variants of COMT and BDNF: a longitudinal study in a population-based sample of older adults

Das, Debjani; Bielak, Allison; Cherbuin, Nicolas; Easteal, Simon; Tan, Susan (Xiaoyun); Anstey, Kaarin


Genetic differences play a significant role in generating individual differences in cognitive abilities. Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. However, not all studies support these associations and hence, the impact of these polymorphisms on cognition is unclear. Here, we investigated the effect of COMT VAL158MET...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Psychology and Aging
DOI: 10.1037/a0035702


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