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The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo

Theodoratos, Angelo; Blackburn, Anneke; Coggan, Marjorie; Cappello, Jean; Larter, Claire; Matthaei, Klaus; Board, Philip


Glutathione transferase Kappa (GSTK1-1) also termed disulfide bond-forming oxidoreductase A-like protein (DsbA-L) has been implicated in the post-translational multimerization of adiponectin and has been negatively correlated with obesity in mice and humans. We investigated adiponectin in Gstk1-/- mice and surprisingly found no difference in the levels of total serum adiponectin or the level of high molecular weight (HMW) multimers when compared with normal controls. Non-reducing...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: International Journal of Obesity
DOI: 10.1038/ijo.2011.267


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