Skip navigation
Skip navigation

Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers

McKay, Michael; Xu, Huiling; Yan, Max; Patra, Jennifer; Natrajan, Rachael; Yan, Yuqian; Swagemakers, Sigrid; Tomaszewski, Jonathan; Verschoor, Sandra; Millar, Ewan KA; van der Spek, Peter


Introduction: RAD21 is a component of the cohesin complex, which is essential for chromosome segregation and error-free DNA repair. We assessed its prognostic and predictive power in a cohort of in situ and invasive breast cancers, and its effect on chemosensitivity in vitro.Methods: RAD21 immunohistochemistry was performed on 345 invasive and 60 pure in situ carcinomas. Integrated genomic and transcriptomic analyses were performed on a further 48 grade 3 invasive cancers. Chemosensitivity was...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Breast Cancer Research (Online edition)
DOI: 10.1186/bcr2814


File Description SizeFormat Image
01_McKay_Enhanced_RAD21_cohesin_2011.pdf1.25 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator