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Flightless I deficiency enhances wound repair by increasing cell migration and proliferation

Cowin, Allison; Adams, Damian H; Strudwick, Xanthe L; Chan, Huater (Walter); Hooper Jones, Jane; Sander, Guy R; Rayner, T E; Matthaei, Klaus; Powell, Barry C; Campbell, Hugh

Description

Wound healing disorders are a therapeutic problem of increasing clinical importance involving substantial morbidity, mortality, and rising health costs. Our studies investigating flightless I (FliI), a highly conserved actin-remodelling protein, now reveal that FliI is an important regulator of wound repair whose manipulation may lead to enhanced wound outcomes. We demonstrate that FliI-deficient +/- mice are characterized by improved wound healing with increased epithetial migration and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/54217
Source: Journal of Pathology
DOI: 10.1002/path.2143

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