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The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

Liu, Dan; Hewawasam, Ruwani; Karunasekara, Yamuna; Casarotto, Marco; Dulhunty, Angela; Board, Philip


The muscle-specific glutathione transferase GSTM2-2 modulates the activity of ryanodine receptor (RyR) calcium release channels: it inhibits the activity of cardiac RyR (RyR2) channels with high affinity and activates skeletal RyR (RyR1) channels with low affinity. The C terminal domain of GSTM2-2 (GSTM2C) alone physically binds to RyR2 and inhibits its activity, but it does not bind to RyR1. We have now used yeast two-hybrid analysis, chemical cross-linking, intrinsic tryptophan fluorescence...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2012.02.020


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