Determinants of attenuation in the envelope protein of the flavivirus Alfuy
Prow, Natalie A; May, Fiona J; Westlake, Daniel J; Hurrelbrink, Robert J; Biron, Rebecca M; Leung, Jason J; McMinn, Peter C; Clark, David C; Mackenzie, John S; Lobigs, Mario; Khromykh, Alexander A; Hall, Roy A
Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus endemic to Australia and Papua New Guinea. Most strains of MVEV cause potentially fatal cases of encephalitis in humans and horses, and have been shown to be highly neuroinvasive in weanling mice. In contrast, the naturally occurring subtype Alfuy virus (ALFV) has never been associated with human disease, nor is it neuroinvasive in weanling mice, even at high doses. To identify viral factors associated with ALFV attenuation,...[Show more]
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|Source:||Journal of General Virology|
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