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L-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts

Berglund, Lucinda J.; Avery, Danielle T; Ma, Cindy; Moens, Leen; Deenick, Elissa; Bustamante, Jacinta; Wong, Melanie; Adelstein, Stephen; Arkwright, Peter D; Bacchetta, Rosa; Cook, Matthew


B-cell responses are guided by the integration of signals through the B-cell receptor (BCR), CD40, and cytokine receptors. The common γ chain (γc)-binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction of tran

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2013-06-506865


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