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Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes

Nekrasov, Maxim; Klymenko, Tetyana; Fraterman, Sven; Papp, Bernadett; Oktaba, Katarzyna; Kocher, Thomas; Cohen, Adrian; Stunnenberg, Hendrik G; Wilm, Matthias; Muller, Jurg


PRC2 is thought to be the histone methyltransferase (HMTase) responsible for H3-K27 trimethylation at Polycomb target genes. Here we report the biochemical purification and characterization of a distinct form of Drosophila PRC2 that contains the Polycomb

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: EMBO Journal, The
DOI: 10.1038/sj.emboj.7601837


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