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Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells

Patnala, Radhika; Lee, Sung; Ohms, Stephen J; Chen, Long; Dheen , Thameem S.; Rangasamy, Danny; Dahlstrom, Jane


Long Interspersed Elements (L1 elements) are biologically active retrotransposons that are capable of autonomous replication using their own reverse transcriptase (RT) enzyme. Expression of the normally repressed RT has been implicated in cancer cell growth. However, at present, little is known about the expression of L1-encoded RT activity or the molecular changes that are associated with RT activity in the development of breast cancer. Here, we report that RT activity is widespread in breast...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Breast Cancer Research and Treatment
DOI: 10.1007/s10549-013-2812-7


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