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Nucleosome binding and histone methyltransferase activity of Drosophila PRC2

Nekrasov, Maxim; Wild, Brigitte; Muller, Jurg


The Drosophila Polycomb group protein E(z) is a histone methyltransferase (HMTase) that is essential for maintaining HOX gene silencing during development. E(z) exists in a multiprotein complex called Polycomb repressive complex 2 (PRC2) that also contains Su(z)12, Esc and Nurf55. Reconstituted recombinant PRC2 methylates nucleosomes in vitro, but recombinant E(z) on its own shows only poor HMTase activity on nucleosomes. Here, we investigate the function of the PRC2 subunits. We show that PRC2...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: EMBO Reports
DOI: 10.1038/sj.embor.7400376


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