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Replicated Effects of Sex and Genotype on Gene Expression in Human Lymphoblastoid Cell Lines

McRae, Allan F.; Matigian, Nicholas A.; Vadlamudi, Lata; Mulley, John C.; Mowry, Bryan; Martin, Nicholas G.; Berkovic, Sam F.; Hayward, Nicholas K; Visscher, Peter M


The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with previous broad sense heritability estimates. The effect of sex on gene expression levels was most noticeable on the X chromosome, which contained 15 of the 20 significantly differentially expressed...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Human Molecular Genetics
DOI: 10.1093/hmg/ddl456


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